P-methoxybenzeneacetonitrile was prepared in 34. 8% yield starting from anisole, via chloromethylation, cyanogenation and fractional distillation.

以苯甲醚为,过氯甲基化,氰化反应后,通过精馏获得甲氧基苯乙腈,总收率为34.8%。